Annual Reports in Medicinal Chemistry, 2 by C K Cain

By C K Cain



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Domino, Anesthesia Analgesia, C u r r e n t R e s . , 45, 29 (1966). 44. D. R . Metcalf, R. N. E m d e a n d J. T. Stripe, Electroencephalog. Clin. , 20, 506 (1966). 45. G. L. G e s s a , L r V a r q u i , F. Crabai, G. C. B o e r o , F. Caboni and R . Camba, Life S c i . , 5, 1921 (1966). 5, 46. H. Sprince, J . A . J o s e p h s , J r . and C. R . , 2041 (1966). 47. J . Boureau, Anesthesie Analgesie, Reanimation, 23, 573 (1966). 23, 565 48. E. Dumoulin, L. L e c r o n , D. Levy and M. , ( 1966).

A . S a l i c lates - There w a s a continued i n t e r e s t i n asc e r t a i n i n g t e c a u s e of g a s t r i c b l e e d i n g a f t e r t h e i n g e s t i o n of a s p i r i n and o t h e r s a l i c y l a t e s . G a s t r i c e r o s i o n s appear t o r e s u l t when t h e rate of l o s s of s u r f a c e c e l l s exceeds t h e replacement rate52, Sodium s a l i c y l a t e induces a h e a r i n g of t h e v i l l u s e p i t h e l i u m from the u n d e r l y i n g mucosa5’ and i n t e r f e r e s a i t h mucoprotein s y n t h e s i s i n t h e g a s t r o i n t e s t i n a l tract These changes may be caused by a blood borne factor53.

2 4 9 , 305 (1965). 9. D. Lorenz, P h a r m . Zeitung, 111, 832 (1966). 10. A r s Medici, 21, 96 (1966) LUnlisted Drugs, 19, 2 (1967)]. 11. J. R. B o i s s i e r , R. Ratouis and C. Dumont, Ann. P h a r m . F r a n c . , 6. 7. 196, - 24, - 57 (1966). 12. Swiss P a t e n t 393,306, October 30, 1965 to D r . A. Wander. 13. H. Hoffmann, Arch. Intern. Pharmacodyn, 180 (1966). 63, 4 5 4 (1966). 14. H. S. Feldman, J . Med. SOC. New J e r s e y , 15. €3. B r i c a i r e and M. , 74, 2695 (1966). 25, 16.

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